Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological objectives and you will pharmacology from curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the major component of the fresh yellow color off turmeric, an enthusiastic Indian spruce that is extracted from this new rhizome of one’s tropical plant Curcuma longa, hence is one of the Zingiberaceae members of the family. Contained in this part, we discuss the pharmacological activities away from curcumin and miten poistaa tilini latin woman dateista you will talk about the latest molecular angles for these products. I up coming review the fresh new proven and you will potential scientific uses out of curcumin. Curcumin is famous usually due to the fact a curative broker, but their apparatus away from step was outlined. The latest pharmacological outcomes of curcumin be seemingly the result of a beneficial synergism out-of companies of weak biochemical affairs which have multiple physical goals for the interrelated signaling routes. These needs are enzymes such as for example cyclooxygenase, lipoxygenase and you will protein kinases, and you will transcription activities such as for instance NF-?B, STAT and you will Nrf2. Modulation of those particles affects downstream affectors that produce this new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial points off curcumin. This type of effects were examined inside health-related examples away from curcumin to own aches and you may inflammatory infection, disease, Alzheimer condition, aerobic ailment, and diabetic issues. This new samples used adjustable amounts from curcuminwith some other frequencies and you may course, toward general achievement that high doses regarding curcumin on level of grams must receive healing outcomes. Find out more
Curcumin: Synthesis, Emerging Role when you look at the Discomfort Management and you will Health Effects
Publication Section Examples of plant-derived pharmaceuticals that have get to be the interest out-of proceeded and you can rapid research and you can invention attract has, to date, already been quite scarce. After several years, the final two decades had been described as a good 100-flex rise in the amount of scientific posts had written per year one is actually of importance to your entry to curcumin inside biomedicine. Read more
Design, synthesis and biological products out of curcumin prodrugs
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences and could has actually therapeutic programs in a lot of condition claims, because the discussed in detail in the earlier section. But not, the possibility health-related efficacy out of curcumin is limited by the its physicochemical attributes of worst drinking water solubility and instability, and this end up in lower bioavailability. Prodrugs from curcumin promote an effective way to improve of biopharmaceutical and you can pharmacokinetic qualities, and may ensure it is exploitation of your own pharmacological aftereffects of curcumin. Within section, we earliest remark the fresh physicochemical and pharmacokinetics regarding curcumin. I following identify the design of curcumin prodrugs with increased liquid solubility and improved chemicals balances which are often converted back to 100 % free curcumin abreast of bioactivation from inside the vivo. We high light previous achievement in this area, which have a concentrate on the framework, synthesis and you can comparison from prodrugs centered on promoieties also amino acids, essential fatty acids, nucleic acids, dicarboxylic acids, and polymeric product such as for instance hyaluronic acid and you may polyethylene glycol. This part has the reason for optimisation of the physicochemical and biopharmaceutical attributes in addition to physiological factors of curcumin prodrugs, towards purpose having fun with of these curcumin types within the scientific apps. Read more
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